Single psilocybin trip delivers two years of depression relief for cancer patients
Phase 2 trial reveals that a single dose of psilocybin offers long-term relief from symptoms of depression and anxiety.
- Date:
- June 16, 2025
- Source:
- Wiley
- Summary:
- Psilocybin, the active ingredient in magic mushrooms, might just revolutionize how depression and anxiety are treated in cancer patients. In a groundbreaking trial, a single dose combined with therapy significantly reduced emotional suffering, and these effects often lasted over two years. As follow-up studies expand the research to multiple doses and larger samples, scientists are eyeing a possible new standard of care that merges psychedelics with psychological support.
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New results from a clinical trial reveal that a single dose of psilocybin -- a naturally occurring psychedelic compound found in mushrooms -- can provide sustained reductions in depression and anxiety in individuals with cancer suffering from major depressive disorder. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
People with cancer often struggle with depression. In this phase 2 trial, 28 patients with cancer and major depressive disorder received psychological support from a therapist prior to, during, and following a single 25-mg dose of psilocybin.
During clinical interviews conducted 2 years later, 15 (53.6%) patients demonstrated a significant reduction in depression, and 14 (50%) had sustained depression reduction as well as remission. Similarly, psilocybin reduced anxiety for 12 (42.9%) patients at 2 years.
An ongoing randomized, double-blind trial is currently evaluating up to two doses of 25 mg of psilocybin versus placebo as treatment for depression and anxiety in patients with cancer. This study is building on the single-dose study in an effort to bring a larger majority of the patients into remission of depression and anxiety.
"One dose of psilocybin with psychological support to treat depression has a long-term positive impact on relieving depression for as much as 2 years for a substantial portion of patients with cancer, and we're exploring whether repeating the treatment resolves depression for more than half of the patients," said lead author Manish Agrawal, MD, of Sunstone Therapies. "If randomized testing shows similar results, this could lead to greater use of psilocybin to treat depression in patients with cancer."
Journal Reference:
- Manish Agrawal, Kim Roddy, Betsy Jenkins, Celia Leeks, Ezekiel Emanuel. Long‐term benefits of single‐dose psilocybin in depressed patients with cancer. Cancer, 2025; 131 (12) DOI: 10.1002/cncr.35889
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